Array ( [0] => 14676796 [id] => 14676796 [1] => cswiki [site] => cswiki [2] => Kináza [uri] => Kináza [3] => [img] => [4] => [day_avg] => [5] => [day_diff] => [6] => [day_last] => [7] => [day_prev_last] => [8] => [oai] => [9] => [is_good] => [10] => [object_type] => [11] => 0 [has_content] => 0 [12] => [oai_cs_optimisticky] => ) Array ( [0] => '''Kináza''' (též '''kinasa''') je [[enzym]], který přenáší [[Fosforečnany|fosfátovou]] [[funkční skupina|skupinu]] z vysokoenergetické [[donor]]ové molekuly (např. [[Adenosintrifosfát|ATP]]) na určitou cílovou molekulu ([[Substrát (chemie)|substrát]]). Tento proces se nazývá [[fosforylace]]. [1] => [2] => == Klasifikace == [3] => Obecně kinázy patří do skupiny: EC 2 [[transferáza|transferáz]] – tj. enzymy, které přenášejí funkční skupiny (například [[methyl|metylovou]], [[acetyl]]ovou nebo právě fosfátovou skupinu). Nejvýznamnější{{zdroj?}} skupinou kináz jsou [[Proteinkináza|proteinkinázy]], které přenáší fosfátovou skupinu na hydroxylovou skupinu aminokyselin (serin, threonin, tyrosin) proteinu za vzniku [[esterová vazba|esterové vazby]]. Fosfát se váže nejčastěji na [[hydroxyl|skupinu (-OH)]] postranních řetězců aminokyselin. Podle typu fosforylované aminokyseliny můžeme proteinové fosforylace rozdělit do dvou základních skupin: [4] => * fosforylace [[serin|serínu]]/[[threonin|treonínu]] – [[serin/threonin kináza|serín/treonín kinázy]] [5] => * fosforylace [[tyrosin|tyrozínu]] – [[tyrosinkináza|tyrozínkinázy]] [6] => [7] => Opačnou reakcí k fosforylaci je [[defosforylace]], která je katalyzována skupinou enzymů nazývaných [[fosfatáza|fosfatázy]]. [8] => [9] => == Význam fosforylace == [10] => Zanesení výrazně nabité a přitom relativně malé fosfátové skupiny v cílovém [[Bílkovina|proteinu]] může výrazně ovlivnit jeho konformaci a tím i jeho funkce. Fosforylace / defosforylace proteinů se často používá jako přepínač mezi aktivní a neaktivní (či jinak aktivní) formou proteinu. Kinázy i fosfatázy jsou proto součástí mnoha signalizačních drah. [11] => [12] => == Klasifikace proteinkináz == [13] => === Skupiny kináz{{Citace periodika [14] => | příjmení = Manning [15] => | jméno = G. [16] => | příjmení2 = Whyte [17] => | jméno2 = D. B. [18] => | příjmení3 = Martinez [19] => | jméno3 = R. [20] => | titul = The Protein Kinase Complement of the Human Genome [21] => | periodikum = Science [22] => | datum vydání = 2002-12-06 [23] => | ročník = 298 [24] => | číslo = 5600 [25] => | strany = 1912–1934 [26] => | issn = 0036-8075 [27] => | pmid = 12471243 [28] => | doi = 10.1126/science.1075762 [29] => | poznámka = PMID: 12471243 [30] => | jazyk = en [31] => | url = https://science.sciencemag.org/content/298/5600/1912 [32] => | datum přístupu = 2021-03-21 [33] => }} === [34] => * AGC = obsahuje rodiny PKA, PKG, [[Proteinkináza C|PKC]] [35] => * CAMK = Calcium/calmodulin-dependent protein kinase [36] => * CK1 = Casein kinase 1 [37] => * CMGC = obsahuje rodiny CDK, MAPK, GSK3, CLK [38] => * STE = homolog [[kvasinky|kvasinkových]] kináz Sterile 7, Sterile 11, Sterile 20 [39] => * TK = [[tyrosin kináza|tyrosinkináza]] [40] => * TKL = Tyrosine kinase–like [41] => [42] => === Jména kináz === [43] => (zdroj: [https://web.archive.org/web/20050427073701/http://www.sciencemag.org/cgi/data/298/5600/1912/DC2/1] – pouze některé kinázy) [44] => * ActR = Activin receptor [45] => * ALK = (TK group) Anaplastic lymphoma kinase [46] => * ALK = (TKL group) Activin-like receptor kinase [47] => * AMPK = [[Adenosin]]e monophosphate–activated protein kinase [48] => * Aur = Aurora [49] => * BARK = b-adrenergic receptor kinase [50] => * BLK = B [[lymfocyt|lymphocyte]] [[tyrosin]]e kinase [51] => * BMPR = Bone morphogeneic protein receptor [52] => * BMX = Bone marrow tyrosine kinase gene in [[chromozóm X|chromosome X]] [53] => * BRD = Bromodomain kinase [54] => * BRSK = Brain-selective kinase [55] => * CaMK = [[Calcium]]/[[calmodulin]]-dependent protein kinase [56] => * CAMKK = CaMK kinase [57] => * CCK-4 = Colon carcinoma kinase–4 [58] => * CDK = [[cyklin|Cyclin]]-dependent kinase [59] => * CDKL = Cyclin-dependent kinase–like [60] => * CK = [[kasein|Casein]] kinase [61] => * CLK = [[Cdc2]]-like kinase [62] => * CSFR = Colonystimulating factor receptor [63] => * DAPK = Death-associated protein kinase [64] => * DCAMKL = Doublecortin- and CaMK-like [65] => * DDR = [[Discoidin]] domain receptor [66] => * DMPK = Dystrophia myotonica protein kinase [67] => * DNAPK = [[DNA]]-activated protein kinase [68] => * DRAK = DAPK-related [[apoptóza|apoptosis]]-inducing kinase [69] => * DYRK = Dualspecificity tyrosine phosphorylation–regulated kinase [70] => * EEF2K = [[Eukaryota|Eukaryotic]] elongation factor–2 kinase [71] => * EGFR = [[Epidermal growth factor receptor|Receptor epidermálního růstového faktoru]] [72] => * Eph = [[Ephrin]] receptor [73] => * ERK = Extracellular signal–regulated kinase [74] => * FAK = Focal adhesion kinase [75] => * FGFR = [[Fibroblast growth factor receptor|Receptor fibroblastového růstového faktoru]] [76] => * FRK = Fos-regulatory kinase [77] => * GRK = G protein–coupled receptor kinase [78] => * GSK = [[glykogen|Glycogen]] synthase kinase [79] => * HIPK = Homeodomain-interacting protein kinase [80] => * IKK = I-kB kinase [81] => * ILK = [[Integrin]]-linked kinase [82] => * InsR = [[Inzulin|Insulin]] receptor [83] => * IRAK = [[Interleukin-1]] receptor–associated kinase [84] => * IRE = [[Inositol]]requiring [85] => * IRR = Insulin receptor–related [86] => * JAK = [[Janus]] kinase [87] => * JNK = c-Jun NH2-terminal kinase [88] => * KSR = Kinase suppressor of Ras [89] => * LATS = Large [[tumor]] suppressor [90] => * LIMK = Lim domain–containing kinase [91] => * LMR = [[Lemur]] kinase [92] => * LRRK = [[Leucin]]e rich–repeat kinase [93] => * MAP2K = [[MAP kináza kináza|Mitogen-activated protein kinase kinase]] – MAP kináza kináza [94] => * MAP3K = [[MAP kináza kináza kináza|Mitogen-activated protein kinase kinase kinase]] – MAP kináza kináza kináza [95] => * MAPK = [[MAP kináza|Mitogen-activated protein kinase]] – MAP kináza [96] => * MAPKAPK = MAPK–activated protein kinase [97] => * MARK = [[mikrotubuly|Microtubule]]-associated protein/microtubule affinity–regulating kinase [98] => * MAST = Microtubule-associated [[serin]]e-[[threonin]]e kinase [99] => * MLCK = [[Myosin]] light chain kinase [100] => * MLK = Mixed lineage kinase [101] => * MNK = MAPK-interacting kinase [102] => * MRCK = Myotonic dystrophy–related [[CDC42]]-binding kinase [103] => * MSK = Mitogen- and stressactivated protein kinase [104] => * MuSK = Muscle-specific kinase [105] => * NDR = Nuclear, [[Dbf2]]-related kinase [106] => * NIK = Nuclear factor kB–inducing kinase [107] => * PAK = [[p21]]-activated kinase [108] => * PDGFR = Platelet-derived growth factor receptor [109] => * PDHK = [[pyruvát|Pyruvate]] [[dehydrogenasa|dehydrogenase]] kinase [110] => * PDK = Phosphoinositide-dependent kinase [111] => * PhK = Phosphorylase kinase [112] => * PIKK = Phosphatidylinositol 3-kinase–related kinase [113] => * PKA = Protein kinase A [114] => * PKB = Protein kinase B [115] => * PKC = [[Proteinkináza C|Protein kinase C]] – proteinkináza C [116] => * PKD = Protein kinase D [117] => * PKG = Protein kinase G [118] => * PKN = Protein kinase N [119] => * PKR = Protein kinase, double-stranded RNA–dependent [120] => * PRK = Protein kinase C–related kinase [121] => * PSKH = Protein serine kinase H [122] => * RIPK = Receptor-interacting protein kinase [123] => * ROCK = Rho-associated, coiled-coil–containing kinase [124] => * ROR = Regeneron orphan receptor [125] => * RSK = [[Ribosom]]al protein S6 kinase [126] => * RSKL = RSK-like [127] => * SgK = Sugen kinase [128] => * SGK = Serumand [[glukokortikoid|glucocorticoid]]-regulated kinase [129] => * SRPK = [[Serin]]e-[[arginin]]e splicing factor protein kinase [130] => * SYK = Spleen [[tyrosin]]e kinase [131] => * TAK = Transforming growth factor–b–activated kinase [132] => * TEC = Tyrosine kinase expressed in hepatocellular carcinoma [133] => * TESK = [[Testis]]-specific kinase [134] => * TGFbR = Transforming growth factor–b receptor [135] => * TIE = Tyrosine kinase with [[imunoglobulin|immunoglobulin]] and [[EGF]] repeats [136] => * TIF1 = Transcriptional intermediary factor 1 [137] => * TLK = Tousled-like kinase [138] => * TSSK = Testis-specific serine [139] => [140] => == Reference == [141] => [142] => [143] => == Externí odkazy == [144] => * {{Commonscat}} [145] => * http://www.kinase.com (anglicky) – je tam strom vývoje [http://kinase.com/mouse/ myších kináz (mouse kinome)] a [http://www.kinase.com/human/kinome/ lidských kináz (human kinome)] [146] => * http://www.cellsignal.com – další informace o kinázách (anglicky) (nefunguje ve Firefox) [147] => [148] => {{Pahýl}} [149] => {{Autoritní data}} [150] => [151] => [[Kategorie:Údržba:Články s referencemi v nadpisech]] [152] => [[Kategorie:Kinázy| ]] [] => )
good wiki

Kináza

Kináza (též kinasa) je enzym, který přenáší fosfátovou skupinu z vysokoenergetické donorové molekuly (např. ATP) na určitou cílovou molekulu (substrát).

More about us

About

Expert Team

Vivamus eget neque lacus. Pellentesque egauris ex.

Award winning agency

Lorem ipsum, dolor sit amet consectetur elitorceat .

10 Year Exp.

Pellen tesque eget, mauris lorem iupsum neque lacus.

You might be interested in

,'tyrosin','Proteinkináza C','serin','threonin','dehydrogenasa','defosforylace','Substrát (chemie)','MAP kináza kináza','Myosin','Dbf2','donor','kasein'

Donor

Kasein

Kasein je bílkovina, která se nachází v mléčném výměšku savců, včetně kravského mléka.

Myosin

Serin

Threonin

Tyrosin